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Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a popular concept. However, after surveying the literature from the past 10 years, only 0.7% (median) of the administered nanoparticle dose is found to be delivered to a solid tumour.

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Jul 13, 2018 · As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification.

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Nanotechnology and Nanoparticles in Drug Delivery - Cancer Radiation Therapy: Researchers are investigating the use of bismuth nanoparticles to concentrate radiation used in radiation therapy to treat cancer tumors. Initial results indicate that the bismuth nanoparticles would increase the radiation dose to the tumor by 90 percent.

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This analysis can be applied to optimize nanoparticle delivery, and to determine the time-points at which photothermal or other therapeutic interventions would be most effective. Specifically, the sparsity of the AuNR distribution within the tumor at each time point was quantified from the spatial frequency content of each 2D PTOCT projection ...

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Jul 23, 2019 · Certain tumor types such as glioblastoma multiforme and pancreatic tumor are known to be poorly permeable, making them less accessible for nanoparticle drug delivery. Evidence indicates that small and long-circulating nanoparticles are ideal for taking advantage of the enhanced permeability and retention effect, even in such intractable tumor models.

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delivery efficiency to solid tumors, yet the mean and median delivery efficiencies are only 1.48% and 0.70% of the injected dose (%ID), respectively, according to a study using a nonphysiologically based modeling approach based on pub-

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Jun 03, 2019 · Nanoparticles (NP) can be synthesized from different materials and have generated increasing interest in nanomedicine, mostly as drug delivery systems [1, 2].NP capable of delivering drugs exhibit advantages such as drug stability, increased bioavailability and reduced drug concentrations required to reach the target, thus decreasing side effects [].

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Nov 23, 2020 · This leads to their protection and supports delivery. In the present study, we explore for the first time PEI for antimiR formulation and delivery. We use the branched low molecular weight PEI F25-LMW for the complexation of different antimiRs, and analyse tumor- and metastasis-inhibitory effects of PEI/antimiR complexes in different tumor models.

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drug delivery; cancer therapy; nanomedicine; Nanoparticles (NPs) have offered new approaches to the delivery of cancer therapeutics (1–5).Doxil (≈100 nm PEGylated liposomal form of doxorubicin) and Abraxane (≈130 nm albumin-bound paclitaxel nanoparticle) are two examples of Food and Drug Administration-approved nanoparticle-based therapeutics for solid tumors; their large size compared ...

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Nanoparticle drug delivery focuses on maximizing drug efficacy and minimizing cytotoxicity. Fine-tuning nanoparticle properties for effective drug delivery involves addressing the following factors. The surface-area-to-volume ratio of nanoparticles can be altered to allow for more ligand binding to the surface. [4]

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Apr 23, 2011 · Polyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted to use as a gene delivery system. However, PEI has some defects that are not fit for keeping on gene expression. Therefore, some modifications against PEI properties have been done to improve their application value in gene delivery. In this ...
Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a popular concept. However, after surveying the literature from the past 10 years, only 0.7% (median) of the administered nanoparticle dose is found to be delivered to a solid tumour.
Docetaxel-conjugate nanoparticle, CRXL301, was designed to enhance drug delivery to tumor tissue up to 10 times more docetaxel into tumors than an equivalent milligram dose of commercially available docetaxel. This thus increases the activity and lowers the toxicity profile in patient [24,25].
Magnetic nanoparticle technology also offers the potential to achieve selective and efficient delivery of therapeutic genes by using external magnetic fields. As compared to traditional gene delivery strategies, magnetic drug delivery system has been shown to significantly increase gene delivery to human xenograft tumors models.
Nov 15, 2018 · We show that liposomal nanoparticle-delivered cGAMP (cGAMP-NP) activates STING more effectively than soluble cGAMP. These particles induce innate and adaptive host immune responses to preexisting tumors in both orthotopic and genetically engineered models of basal-like TNBC. cGAMP-NPs also reduce melanoma tumor load, with limited responsivity to anti–PD-L1.

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In solid tumors, increasing drug penetration promotes their regression and improves the therapeutic index of compounds. However, the heterogeneous extracellular matrix (ECM) acts a steric and interaction barrier that hinders effective transport of therapeutics, including nanomedicines. Specifically, the interactions between the ECM and surface physicochemical properties of nanomedicines (e.g ...
Oct 31, 2012 · X-rays are known to interact with metallic nanoparticles, producing photoelectric species as radiosensitizing effects, and have been exploited in vivo mainly with gold nanoparticles. The purpose of this study was to investigate the potential of sensitizing effect of iron oxide nanoparticles for photon activated therapy. X-rays photon activated therapy (PAT) was studied by treating CT26 tumor ...